Pressure from his boss and a skin-cream client produces a talking boil on a British adman's neck.
When Pericles discovers the dread answer to Antioch's riddle, he flees for his life straight into famine, shipwreck, love, fatherhood, and another shipwreck; he loses his wife and daughter, and doesn't find them again until the story moves us through resurrection, attempted murder, pirates, prostitution, and divine revelation.
For years after her father's disappearance, the beautiful Miss Mary Morstan receives anonymously every year one large and valuable pearl. When, finally, an invitation arrives to meet the mysterious pearl-giver, Mary Morstan seeks Holmes's advice, and he begins to unravel some remarkable clues, including a poison dart and a man with a wooden leg. What Holmes finds is an old soldier who is determined to punish those who betrayed him and his friends by stealing their oriental treasure.